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Selected for the Front Cover: Journal of Agricultural and Food Chemistry, Volume 69, Number 33

  • 執筆者の写真: Mindy Takamiya
    Mindy Takamiya
  • 2021年8月4日
  • 読了時間: 1分

Inhibiting bile acid reabsorption with ASBT, an apical sodium-dependent bile acid transporter, is regarded as one strategy to reduce plasma cholesterol levels. In this study, we screened polyphenols and revealed that teaflavins, a polymer of oxidized catechin which is common in black tea, inhibit bile acid uptake by directly interacting with ASBT. This study also elucidated the mechanism by which this happens.
Inhibiting bile acid reabsorption with ASBT, an apical sodium-dependent bile acid transporter, is regarded as one strategy to reduce plasma cholesterol levels. In this study, we screened polyphenols and revealed that teaflavins, a polymer of oxidized catechin which is common in black tea, inhibit bile acid uptake by directly interacting with ASBT. This study also elucidated the mechanism by which this happens.

"Modulatory Effect of Theaflavins on Apical Sodium-Dependent Bile Acid Transporter (ASBT) Activity"

Yuki Takashima, Kazuki Ishikawa, Rina Miyawaki, Mana Ogawa, Takeshi Ishii, Takumi Misaka, and Shoko Kobayashi*

Journal of Agricultural and Food Chemistry 2021, 69, 33, 9585-9596

Publication Date (Web): August 4, 2021 https://pubs.acs.org/doi/full/10.1021/acs.jafc.1c03483


 
 
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